Does
Plasmodium falciparum the parasite that causes the most severe form of malaria
leading to the death of a child every 60 second have an Achilles? heel that can be exploited therapeutically?
The answer seems to be yes even though the bug enjoys three layers of
protection by the red cell membrane (RCM), the parasitophorous vacuole membrane(PVM), and the parasite plasma membrane (PPM).
On the basis of the molecular
structure of the bug’s? PPM
and the quantitative mechanics of its major intrinsic membrane protein
interacting with erythritol, I hypothesize that erythritol the generally considered safe sugar substitute
could be the weapon needed to deliver a
fatal attack on the heel of the parasite that is responsible for about a
million deaths a year. Currently,
all malaria drugs used or researched for are intricate compounds that have
strong side effects and induce drug-resistance in the parasites . Researchers
have not considered the possibility that the benign erythritol can kill or
impede the growth of P. falciparum. Read more.........................
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