Wednesday, 9 November 2016

Does Plasmodium falciparum have an Achille’s Heel?

Does Plasmodium falciparum the parasite that causes the most severe form of malaria leading to the death of a child every 60 second  have an Achilles? heel that can be exploited therapeutically? The answer seems to be yes even though the bug enjoys three layers of protection by the red cell membrane (RCM), the parasitophorous vacuole membrane(PVM), and the parasite plasma membrane (PPM). 
Plasmodium falciparum

On the basis of the molecular structure of the bug’s? PPM and the quantitative mechanics of its major intrinsic membrane protein interacting with erythritol, I hypothesize that erythritol  the generally considered safe sugar substitute  could be the weapon needed to deliver a fatal attack on the heel of the parasite that is responsible for about a million deaths a year. Currently, all malaria drugs used or researched for are intricate compounds that have strong side effects and induce drug-resistance in the parasites . Researchers have not considered the possibility that the benign erythritol can kill or impede the growth of P. falciparum. Read more.........................

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