Immunogenic and Protective Properties of Recombinant Proteins Based on Meningococcal Iga1 Protease

At present, meningitis is a frequent neuroinfection, and the most widely distributed bacteria-caused meningitis (up to 56%) is a socially dangerous disease. Due to existence of vaccines against meningitis caused by the meningococcus serogroups A, C, Y, W135 which are based on their capsular polysaccharides  and to creation of the protein-based polycomponent serogroup B monovaccine, there is a possibility ofpreventing the meningococcal infection caused by the epidemically mostdangerous serogroups. 

However, all currently used vaccines are, as a rule, targeted rather narrowly against a specific infectious agent. Besides, such vaccination creates for a human organism an enormous antigenic load, and therefore, it is necessary to search for variants of a polyvalent vaccine which would be capable of protecting against the variety of circulating and permanently mutating meningococcus strains.  Thus, the search for new approaches for preventing the meningococcal infection is still urgent.The bacterial IgA1 protease (IgA1pr) which is the major virulence factor of many pathogens was earlier proposed as a basis for such polyvaccine. Read more.................