Tuesday, 16 August 2016

Determination of Neutral Lipid and Cluster Formation for Screening Neurocognitive Impairment in Human Immunodeficiency Virus Patients

Human immunodeficiency virus (HIV) is an infection that weakens the immune system, making it harder for the body to fight infections and disease. It has neurotoxic effects, thus it is not surprising that HIV infection can cause problems including neurocognitive impairment (NCI) anddementia. Prior to widespread availability of combination antiretroviral therapy (cART), the prevalence of HIVassociated dementia was estimated to be between 6 - 30% among HIV positive patients . With the advent of cART, the most severe forms of HIV-associated dementia significantly decreased in prevalence, but milder forms of impairment remain highly prevalent and increase with age, affecting about 30 - 60% of HIV patients. It has, however, to be noted that there is current discussion about the prevalence of neurocognitive dysfunction, which might be under- or overestimated, depending on the neurocognitive assessment tools used. In addition, compared to the first decade of the epidemic, a shift has occurred .

Standardcomprehensive neuropsychological test batteries exist for the assessment of NCI in HIV patients. However, more extensive neuropsychological test batteries, although very useful in highlighting neurocognitive impairment, are difficult to apply in every clinical setting, because they require neuropsychological and neurological expertise and are influenced by differences in education, culture, and language across borders, and there is a lack of appropriate normative data for many patient populations. 

1 comment:

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