Oral Protocol for Successful Desensitization of Metronidazole

Trichomoniasis is the most prevalent nonviral sexually transmitted infection. Metronidazole and tinidazole are the only medications that are recommended by the Centers for Disease Control for the treatment of trichomoniasis. Alternative therapies are not standardized and limited in efficacy. Skin-prick testing to metronidazole is not validated. Three metronidazole desensitization protocols have been described, including one intravenous and two oral protocols. 

Centers for Disease Control and Prevention published a study documenting a total of 127 patients with suspected metronidazole hypersensitivity, among whom 15 patients underwent metronidazole desensitization2. Among those 15 patients, 7 patients underwent a 14-dose intravenous protocol3 and 8 patients underwent an 8-dose oral protocol5. All 15 patients achieved infection cure. More recently, a 12- dose modified oral desensitization protocol was described by Gendelman and colleagues in 2014. For more information Insights in Allergy, Asthma & Bronchitis.Read more.......