Pathogenesis in Ebola virus disease

Ebola virus disease (EVD) caused by Ebola viruses (EBOV) is one of the most dangerous infection with mortality rates up to 90%. Pathogenesis of Ebola is not through cell division; instead they insert their genetic information into DNA of the host cell and eventually hijack all cellular processes.As new viral capsules are formed and bud out from the host cell and act against host immune system. Symptoms of EVD include fever, headache, life-threatening bleeding and multi-organ failure.Till now there are no approved treatments or vaccines available for EVD. However bunch of therapies are available for prevention and control.

Ebola virus disease (formerly called Ebola Hemorrhagic Fever) is a severe, often fatal, disease in humans and nonhuman primates, which is caused by the Ebola virus. Between 1976 and 2014 twenty-fourepidemics of Ebola virus disease (EVD) were verified, mostly caused by Zaire Ebola virus (ZEBOV) in Equatorial Africa. Most outbreaks have been small, but the virus captured the attention of the world due to death rates that can be as high as 90% as well as the visceral manner in which it kills.

In March 2014, World Health Organization (WHO) reported a major Ebola outbreak in Guinea, Liberia and Sierra Leone, western African nations. The 2014 EVD outbreak in West Africa caused by ZEBOV is the longest, largest, deadliest, and the most complex in history. As of 11 February 2015, there were 22,859 EVD cases and a total of 9,162 deaths. Compared to the cumulative sum of past episodes in 36 years (1976-2012), 2,232 infected people and 1,503 deaths there are now over ten times the total number infection cases and over six times the total number of fatalities. The Ebola virus disease outbreak in West Africa affected impoverished post-conflict countries with weak health systems and no experience with Ebola. Read more....................