HIV-1 Capsid as a Target for Antiviral Therapy

Human immunodeficiency virus type 1 (HIV-1) is the causative virus responsible for acquired immune deficiency syndrome (AIDS), for which there is still no protective vaccine.

Since 1983, more than34 million people have been infected with HIV across the world, with 1.5million people dying as a result of complications from infection each year. HIV-1 virions mainly infect cells of the immune system and lead to a gradual reduction in the proportion of CD4+ T cells. This in turn causes a significant decrease in the patient’s ability to mount an immune response, and they die as a result of opportunistic infection. HIV-1 thus remains a major pathogenic threat to human health worldwide.  Read more>>>>>>>>>>>>>