Tuberculosis
(TB), the world’s deadliest communicable disease with an estimated 9.0 million
cases of TB and 1.5 million deaths in 2013 throughout the world. TB is a major health issue in resource limited countries. Despite immense progress in medical
sciences and improved health care facilities in developed countries, TB remains
one of the biggest challenges in resource poor setting and developing countries.
One of the obvious reasons for this dilemma is the involvement of multiple
factors in increasing the susceptibility of infection and progression of the
disease. Pathogenesis of TB in man is a two stage process. In the first stage,
the infection is initiated when a person is exposed to an infected individual
and inhales the virulent bacterium through sneezing and coughing of an infected
individual. Inhalation of droplet nuclei that are smaller enough (1-2 µm) to
reach the alveolar surface of the lower respiratory tract can cause the
infection. Read more>>>>>>>
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