Why is Therapeutic Drug Monitoring for Voriconazole Essential in the Treatment of Fungal Infections

Fungal infections are frequent life-threatening complications in immune compromised patient sand in patients admitted in ICU wards. Voriconazole (VRC) is a second-generation wide-spectrum antifungal triazole recommended for the treatment of potentially life threatening fungal infections including invasive aspergillosis,disseminated candidasies, and other infections caused by Fusarium and Scedosporium spp. 

 

Fungal Infections

This compound can be administered as an intravenous infusion and oral formulations. Studies with healthy volunteers demonstrated bioavailability of >90% after oral administration. A steady-state level is achieved in three days with two loading doses of 400 mg for the first day, followed by a maintenance dose of 200 mg every 12 hours thereafter. Investigations have shown both within and between individual's variability in VRC steady-state plasma concentration and non-linear pharmacokinetics due to saturation of its metabolism with respect to dose. Read More>>>>>>>