Of
40 million people living worldwide with a Human Immunodeficiency Virus (HIV)
infection approximately 2.3 million are chronically co-infected with the Hepatitis C Virus (HCV).
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| Microarrays-Enabled Hypothesis Generation |
HIV/ HCV co-infected patients demonstrate higher
rates of neuropsychiatric illness (NI, such as generalized anxiety disorder,
dysthymia, panic disorder, major depression and substance abuse disorder)
relative to HIV mono-infected subjects or the general population. In previous
research, we identified gene expression profiles significantly modulated in
HIV/HCV co-infected patients who experienced pegylated interferon-α
(PegIFN-α)-induced NI and were able to characterize the unique role of
Interferon-stimulated-exonuclease-gene 20 kDa (ISG20) in linking
PegIFN-α-related NI to distinct HCV treatment responses in patients co-infected
with HIV and HCV. Read More>>>>>>>
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