Nontuberculous
mycobacteria (NTM) cause chronic pulmonary involvement. Mycobacterium
avium-intracellulare complex (MAC) comprises approximately 70% of NTM cases and M. kansasii comprises approximately 20%. MAC is an intracellular proliferating
pathogen that causes chronic progressive respiratory infection as well as
disseminated diseases in HIV patients.
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Nontuberculous Mycobacteria |
Pulmonary MAC disease causes pulmonary
involvement, such as bronchiectasis and small nodules, particularly in the
middle lobe and lingular segment. Several reports have demonstrated a 59-92%
response rate for a clarithromycin-containing regimen. However, relapses after
medical therapy with treatment regimens are common. Some parts of the lung
involvement are frequently resolved, whereas other parts are progressive. This
phenomenon makes the evaluation of the treatment for MAC infection difficult. Read more>>>>>>>>>
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