The Mutant virus Mu-3, isolated from the srr7
virus (srr7), causes the apoptosis of pyramidal neurons in CA2 and CA3subregions of the hippocampus after infection. Apoptosis of the pyramidal
neurons in the hippocampus is observed after infection with various kinds of
viruses, as introduced in our previous report.
 |
| Figure(1) |
 | |
| Figure(2) |
It has been considered that the
apoptotic lesions after infection are not caused by the direct infection of
neurons, but induced through indirect effects, triggered by immune responses
that involve elevated levels of proinflammatory cytokines detected in the
course of diseases. However, our study using the homogenized tissue or frozen
sections obtained from Mu-3-infected mice failed to detect the production of
proinflammatory cytokines in CA2 and CA3 subregions of the hippocampus.
Thereafter, we examined the involvement of anti-inflammatory cytokines, and
found that IL-10 is expressed in pyramidal neurons in CA2 and CA3 subregions of
the hippocampus. Read more>>>>>>>>>>>>
No comments:
Post a Comment